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Identification and quantitation of impurities in dapsone preparations

✍ Scribed by G. R. Gordon; D. C. Ghoul; J. H. Peters

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
336 KB
Volume
64
Category
Article
ISSN
0022-3549

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✦ Synopsis

Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4'-diaminodiphenyl sulfone and 4-aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4'-diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high-pressure liquid chromatography.

Keyphrases Dapsone-isolation, identification, and quantitation, pharmaceutical preparations TLC-determination, dapsone impurities in pharmaceutical preparations 0 High-pressure liquid chromatography-determination, dapsone impurities in pharmaceutical preparations . .

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