“Construction of the Simplest Model to Explain Complex Receptor Activation Kinetics” [Journal of Theoretical Biology 218 (2002) 139–147]

✍ Scribed by R.P. BYWATER; A. SORENSEN; P. ROGEN; P.G. HJORTH

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 49 KB
• Volume: 221
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.2003.3204

✦ Synopsis

Erratum ''Construction of the Simplest Model to Explain Complex Receptor Activation Kinetics'' [Journal of Theoretical Biology 218 (2002) 139-147]

The publisher regrets that the abstract in the above-mentioned article erroneously mentioned ''reactor'' instead of ''receptor''. The correct version is herewith given.

We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor models. Focusing on the predic-tion of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exhibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.