Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones
✍ Scribed by William J. Lominac; Megan L. D’Angelo; Mark D. Smith; Darius A. Ollison; James M. Hanna Jr.
- Book ID
- 113930407
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 495 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
An expedient method for the synthesis of 2-phenyl-5-aryl-2,3-dihydropyrazolo [3,4-b]pyridin-3-ones and 2-phenyl-3-oxo-2,3-dihydropyrazolo[3,4-b]pyridine-5-carbaldehyde in a single-step via condensation of vinamidinium salts with 3-amino-1-phenyl-2-pyrazolin-5-one is described.
## Abstract For Abstract see ChemInform Abstract in Full Text.
A facile, solvent free, ecofriendly approach for the synthesis of 2-amino-3(ethylcarboxy)-4,6-disubstituted pyridine 4 and pyrazolo [3,4-b]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it comp