The synthesis of fragments, comprising two and four repeating units, of the title polysaccharide Is described. A recent report' describing the synthesis of the Me compounds prompts us to disclose our own work, which differs in some aspects from the synthesis published by Hoogerhout et a/'. In our
Construction of Fab fragments with specificity for Haemophilus influenzae type B capsular polysaccharide (HIbCP)
β Scribed by Lotte Hougs; Lars Juul; Torben Barington; Ame Svejgaard
- Book ID
- 108408947
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 183 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0165-2478
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π SIMILAR VOLUMES
The synthesis of the ribosyl-ribitol derivatives 12 and 1,7 (Scheme 2) is presented. The compounds served as building blocks for the preparation of protected fragments(2\_4, n=l or 2; Fig. 2) of the title polysaccharide. The bifunctional reagent bi.sCl-benzotriazolyll-Zchlorophenylphosphate (l\_S,
The synthesis of the monomeric fragment of the Haemophilus injluettzae type b (HIb) polysaccharide starting from orthoacetate I. is described. The construction of the dimer is also reported. The poly-(ribosyl-ribitol-phosphate) (PRP) 1. capsular polysaccharide isolated from the Haemophilus inj7uenza