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Construction of bicistronic lentiviral vectors for tracking the expression of CDNF in transduced cells

✍ Scribed by Fernández, Anllely; Guzmán, Sheyla; Cruz, Yocelin; Zamorano, Pedro

Book ID: 126265195
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 668 KB
Volume: 76
Category: Article
ISSN: 0147-619X
DOI: 10.1016/j.plasmid.2014.09.001

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## Abstract In this study we have developed and validated a novel approach of transgene regulation in the brain. By using lentiviral vectors that incorporate promoters of genes that are up‐regulated during different pathological states, we were able to regulate transgene expression in accordance wi