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Constructing Chiral Diazoacetoacetates by Enantioselective Catalytic Mukaiyama Aldol Reactions.

✍ Scribed by Kousik Kundu; Michael P. Doyle


Publisher
John Wiley and Sons
Year
2006
Weight
16 KB
Volume
37
Category
Article
ISSN
0931-7597

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Organocatalyzed Highly Enantioselective
✍ Ning Zhu; Bao-Chun Ma; Yong Zhang; Wei Wang πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 177 KB πŸ‘ 1 views

## Abstract The formation of chiral γ‐butenolides has been achieved with good yields (up to 90%), high enantioselectivity (up to 91%) and diastereoselectivity (up to 9/1, __anti__‐selective) through an organocatalyzed vinylogous Mukaiyama aldol reaction of 2‐(trimethylsilyloxy)furan and aldehydes.