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Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation

✍ Scribed by Sai Prasad Pydi; Rajinder Pal Bhullar; Prashen Chelikani


Book ID
115270859
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
595 KB
Volume
122
Category
Article
ISSN
0022-3042

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This work compares the structuralrdynamics features of the wild-type Ž . ␣1b-adrenergic receptor AR with those of the D142A active mutant and the agonistbound state. The two active receptor forms were compared in their isolated states as well as in their ability to form homodimers and to recognize t