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Constitutive mutation of cysJIH operon in a cysB deletion strain of Salmonella typhimurium

✍ Scribed by Ostrowski, Jack ;Hulanicka, Danuta

Publisher: Springer
Year: 1979
Tongue: English
Weight: 418 KB
Volume: 175
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00425530

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✦ Synopsis

In a cysB deletion strain a new mutation, denoted cys-2332 was isolated, which causes the constitutive expression of the cysJIH operon. cys-2332 is closely linked to cysJIH and presumably is located in the initiator region of this operon, rendering its expression independent of the cysB gene product and the internal inducer O-acetyl-L-serine. The presence of sulfite reductase (encoded by cysI and cysJ) activity in a cysB- cys-2332 double mutant indicates that cysG, which is not linked to cysJIH but is required for the synthesis of the sulfite reductase co-factor siroheme, is not controlled by cysB.

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