Generation of RNA Aptamers to the G-Prot
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Dion A. Daniels; Awinder K. Sohal; Stephen Rees; Reinhard Grisshammer
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Article
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2002
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Elsevier Science
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English
β 230 KB
G-protein-coupled receptors (GPCRs) are integral membrane proteins involved in signal transduction and constitute major drug targets for disease therapy. Aptamers, which are globular RNA or DNA molecules evolved to specifically bind a target, could represent a valuable tool with which to probe the r