Constitutional retinoblastoma gene deletion in Egyptian patients
✍ Scribed by Amal M. Mohammed; Alaa K. Kamel; Saida A. Hammad; Hanan H. Afifi; Zeinab El Sanabary; Mostafa Ezz El Din
- Book ID
- 107659836
- Publisher
- SP Children’s Hospital, Zhejiang University School of Medicine
- Year
- 2009
- Tongue
- English
- Weight
- 221 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1708-8569
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Approximately 10% of B-cell chronic lymphocytic leukemia (B-CLL) cases have structural chromosomal aberrations involving band 13q14. To evaluate a possible role of RBI gene deletions in B-CLL we investigated the malignant cells of 27 patients by molecular genetic and cytogenetic techniques. Four of
## Communicated by Daniel F. Schorderet Constitutional mutations in the RB1 gene predispose to retinoblastoma development. Hence genetic screening of retinoblastoma patients and relatives is important for genetic counseling purposes. In addition, RB1 gene mutation studies may help decipher the mol