Constitutional nonsense germline mutations in the RB1 gene detected in patients with early onset unilateral retinoblastoma
β Scribed by J.K. Cowell; H. Cragg
- Book ID
- 116167977
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 749 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have analyzed the 27 exons and the promoter region of the RBI gene in familial or sporadic bilateral retinoblastoma by using single-strand conformation polymorphism analysis. For improvement over previous studies, a new set of primers has been designed, which allow for amplification of the coding
Retinoblastoma is the most common intraocular malignancy in children. It is estimated that 60 percent of cases are nonhereditary and unilateral, 15% are hereditary and unilateral, and 25 percent are hereditary and bilateral. Hereditary predisposition for retinoblastoma is caused by germline mutation