We have analyzed the 27 exons and the promoter region of the RBI gene in familial or sporadic bilateral retinoblastoma by using single-strand conformation polymorphism analysis. For improvement over previous studies, a new set of primers has been designed, which allow for amplification of the coding
Mutational analysis of the RB1 gene in Indian patients with retinoblastoma
β Scribed by Ata-ur-Rasheed, M.; Vemuganti, Geeta K.; Honavar, Santosh G.; Ahmed, Niyaz; Hasnain, Seyed E.; Kannabiran, Chitra
- Book ID
- 115523258
- Publisher
- Informa plc
- Year
- 2002
- Tongue
- English
- Weight
- 202 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1381-6810
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Retinoblastoma is the most common primary intraocular malignancy in children, caused by inactivation of the RB1 gene on chromosome 13. We carried out a mutational screen of the exons and promoter of the RB1 gene in Indian patients with retinoblastoma in order to determine the range of mutations givi
lines 9-10: "Eight novel mutations were identified, including 4 single base changesβ¦" This should read: "Eight novel mutations were identified, including 5 single base changesβ¦" 2. Page 3, second line from bottom: "β¦(g.76940del12; IVS15del+20-33) extending from +18 to +32 of the intron (RB72)." Thi