Consistent Hepatic Metastasis of Human Colorectal Cancer in Severe Combined Immunodeficient Mice
โ Scribed by Harvey L. Bumpers; Thomas R. Alosco; Hui-Qun Wang; Nicholas J. Petrelli; Eddie L. Hoover; Richard B. Bankert
- Book ID
- 115635031
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 197 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-4804
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Studies on liver metastasis of human colon cancer are limited because of a lack of suitable animal models. In this study, the usefulness of mice with severe combined immunodeficiency (SCID), which congenitally lack functional T and B lymphocytes, was evaluated in comparison with currently available
We have developed a liver metastatic model of human colon cancer using severe combined immunodeficient (SCID) mice. Liver metastases were observed in all the SCID mice on day 28 after intrasplenic injection with 5 X lo6 dissociated tumor cells of COL-2-JCK, a human colon cancer strain serially trans