## Abstract Germline mutations in the __VHL__ tumor suppressor gene cause von HippelโLindau (VHL) disease and somatic __VHL__ mutations occur in the majority of clear cell renal cell carcinoma (cRCC). To compare copy number abnormalities (CNAs) between cRCC from VHL patients and sporadic cRCC cases
Conservative surgical therapy of localized renal cell carcinoma in von hippel-lindau disease
โ Scribed by Greg O. Lund; Bernard Fallon; Mary A. Curtis; Richard D. Williams
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 475 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
We report the case of a 26-year-old man with von Hippel-Lindau syndrome (VHL) and two renal cell carcinomas (RCC), one of which was studied cytogenetically. Chromosomal analysis of the RCC showed a translocation that involved chromosomes 3 and 8 with subsequent loss of the derivative chromosome 8. T
## Abstract Deletions of 3p25, gains of chromosomes 7 and 10, and isochromosome 17q are known cytogenetic aberrations in sporadic renal cell carcinoma (RCC). In addition, a majority of RCCs have loss of heterozygosity (LOH) of the Von HippelโLindau (__VHL__) gene located at chromosome band 3p25. Pa
## Abstract It has been documented that renal cell carcinomas (RCCs) occur frequently in patients treated with longโterm dialysis, especially in cases of endโstage renal disease (ESRD)/acquired cystic disease of the kidney (ACDK). To address the molecular pathogenesis of ESRD/ACDKโassociated RCCs,
The von Hippel-Lindau gene product (pVHL) interacts with and inhibits the cellular transcription factor elongin. However, the subcellular localization of pVHL has remained uncertain. Naturally occurring pVHL mutants which fail to interact with elongin have been described in patients with VHL disease