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Conservation of MHC class II DOA sequences among carnivores

✍ Scribed by S.J. Soll; B.S. Stewart; N. Lehman


Book ID
110892103
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
83 KB
Volume
65
Category
Article
ISSN
0001-2815

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Narcolepsy has a 98% association with the DR2-Dw2/DQw1 haplotype. To establish if a disease-specific allele is present in narcolepsy, a cDNA library was made from a B-cell line from a DR2,4/DQw1,3 narcoleptic. Clones encoding the two expressed DR2 beta chains, along with DQw1 alpha and beta chains,