Site specificity of binding of antitumor
โ
Martin B. Jones; Ulrich Hollstein; Fritz S. Allen
๐
Article
๐
1987
๐
Wiley (John Wiley & Sons)
๐
English
โ 843 KB
The site specificities for intercalation of steffimycin B, adriamycin, echinomycin, and ethidium bromide with DNA have been determined by CD first-neighbor analysis. The first three, which are antineoplastic antibiotics, all exhibit preferential binding to sites comprised of guanine and cytosine (Gp