Connective tissue growth factor and progressive fibrosis in biliary atresia
β Scribed by Hiroyuki Kobayashi; Nobukazu Hayashi; Kenji Hayashi; Atsuyuki Yamataka; Geoffrey J. Lane; Takeshi Miyano
- Book ID
- 106055179
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 348 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0179-0358
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π SIMILAR VOLUMES
Skin fibrotic disorders are understood to develop under the influence of some growth factors, such as transforming growth factor-beta (TGF-β€), basic fibroblast growth factor (bFGF), or connective tissue growth factor (CTGF). To establish an appropriate animal model of skin fibrosis by exogenous appl
Connective tissue growth factor (CTGF) stimulates in vitro fibroblast proliferation and extracellular matrix synthesis. The aim of this study was to assess the role of CTGF in liver fibrogenesis. CTGF expression was investigated both at the protein and mRNA level in biopsies of chronic liver disease
## Abstract ## Objective Connective tissue growth factor (CTGF) is a cysteineβrich secreted matricellular protein involved in wound healing and tissue repair. Enhanced and prolonged expression of CTGF has been associated with tissue fibrosis in humans. However, questions remain as to whether CTGF