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Conjugates of a Novel 7-Substituted Camptothecin with RGD-Peptides as α v β 3 Integrin Ligands: An Approach to Tumor-Targeted Therapy

✍ Scribed by Dal Pozzo, Alma; Esposito, Emiliano; Ni, Minghong; Muzi, Laura; Pisano, Claudio; Bucci, Federica; Vesci, Loredana; Castorina, Massimo; Penco, Sergio

Book ID: 120991134
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 855 KB
Volume: 21
Category: Article
ISSN: 1043-1802
DOI: 10.1021/bc100097r

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✍ Didier Boturyn; Pascal Dumy 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 105 KB

The cyclopeptide (-RGDfK-) is a potent and selective a V b 3 /a V b 5 integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and fle