Congestive heart failure II

• Publisher: Springer US
• Year: 1991
• Tongue: English
• Weight: 146 KB
• Volume: 5
• Category: Article
• ISSN: 0920-3206
• DOI: 10.1007/bf00055758

✦ Synopsis

ACE-inhibition theoreticalll lay rednce myocardial ischeaia by |odnlatlng nyocardial 02 denned or coronary flow.To better define antiiscbesic efficacy end soda of action in huzans, 24 untreated, nomoteuSive Dis witb CAD uederYent 2 identical increseutal pacing stress tests, 40 tin hefore(?l) and 15 sin after(F2) 1.5 ng halaprilat lv(Gr E,n=12) or plaeehe(Gr P,n=li).Kenedynasic variables and arterial(art) and coronary venous levels of norepinep~lne(llE),epinepl~rine(E),dopasise and angiotensia II (MI) were detersised at control(C) end mazizal pacing rates (~I).AII variables ~ere cosparable in Gr g and Gr P during Yl and were reproducible during both tests in ~r ?. In contrast,iscbenla was slgsJficsntly redhead lu Gr B during 1'2 cotpared with PI(ST segseut -I.L~0.3tV vs -Lh0.3nV, resp.o and lactate estractios -h 9| vs -35-.20|, renp.,nS~). Mso,nyocardial O, estractlen was 171 lens(p<.05 vs P1).K did not affect changes in double product or overall coronary flow,hat abolished ischesiainduced nenrobaorsl activation and subsequent increases in arterial pressure (I~LP) and systemic renistasce(S¥1t) [tp<.05 vs C,~p<.05 F1 vs 1'2].

H: C ~ 1'2: C ]g,l Art gE (ai01/l)