A new glucose-6-phosphate dehydrogenase
✍
Gian Franco Gaetani; Silvana Galiano; Cecilia Melani; Maurizio Miglino; Gian Luc
📂
Article
📅
1990
🏛
Springer
🌐
English
⚖ 405 KB
A new deficient variant of glucose-6-phosphate dehydrogenase (G6PD) causing severe congenital nonspherocytic hemolytic anemia (CNSHA) is described. The variant enzyme, characterized by slow electrophoretic mobility, extreme in vivo and in vitro lability, high Km for G6P and strongly acidic pH optimu