Conformationally restricted analogues of methionine: Synthesis of chiral 3-Amino-5-methylthio-2-piperidones

✍ Scribed by Ricardo Rodríguez; M. Angels Estiarte; Anna Diez; Mario Rubiralta; Anna Colell; Carmen García-Ruiz; JoséC. Fernández-Checa

• Book ID: 104207332
• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 569 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)00340-7

✦ Synopsis

~ ( otR, 3RS, 5S)-3-Amino-N-(2-hydroxy-1-phenylethyl)-5-methylthio-2piperidones 1 have been synthesized from enamide 2 by subsequent free radical addition of methanothiol on position 5 and amination of 3-position.