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Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

✍ Scribed by Stephen R. Bertenshaw; John J. Talley; D.J. Rogier; Matthew J. Graneto; Carol M. Koboldt; Yan Zhang

Book ID: 104364676
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 208 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00530-6

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✦ Synopsis

Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess anfiinflammatory activity in vivo.

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