ChemInform Abstract: Conformationally Restricted 1,5-Diarylpyrazoles are Selective COX-2 Inhibitors.
β Scribed by S. R. BERTENSHAW; J. J. TALLEY; D. J. ROGIER; M. J. GRANETO; C. M. KOBOLDT; Y. ZHANG
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Diarylthiazolo(3,2b) ( 1,2,4)triazoles. -Sixteen title compounds such as (I) are prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. Most of the analogues in the series are very potent against the COX-2 enzyme. All of the compounds exhibit good selectivity in