Conformational study of vasoactive intestinal peptide by computational methods
✍ Scribed by FILIZOLA, MARTA ;CARTENÌ-FARINA, MARIA ;PEREZ, JUAN J.
- Book ID
- 110893530
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 794 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1397-002X
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## Abstract The structural features of vasoactive intestinal peptide (VIP) and of its Gln^16^‐diaminopropane derivative (VIP‐DAP) in solution were investigated by limited proteolysis experiments with trypsin and thermolysin. The proteolysis of the native peptide by both proteinases takes place near
The conformational preferences of peptide T (ASTTTNYT) were analysed by means of computational methods. A thorough exploration of the conformational space was carried out within the framework of the molecular mechanics approach, using simulated annealing as a searching strategy. Specifically, in ord