Conformational study of the complementary peptide to a B-cell epitope of the La/SSB autoantigen
✍ Scribed by Christine Hemmerlin; Angélique Phan Chan Du; Zouhair Elhilali; Avrilia Moulia; Vassilios Tsikaris; Maria Sakarellos-Daitsiotis; Constantinos Sakarellos; Eleni Dotsika; Athanasios G Tzioufas; Haralampos M Moutsopoulos; Manh-Thong Cung
- Book ID
- 104429973
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 116 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1387-1609
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## Abstract La/SSB phosphoprotein is the target antigen of autoantibodies in sera of patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). Among other structural and function motifs, four phosphorylation sites are encompassed in the primary sequence of La/SSB. Two of them (T
## Abstract T‐cell epitopes are important components of the inappropriate response of the immune system to self‐proteins in autoimmune diseases. In this study, the candidate T‐cell epitopes of the La/SSB autoantigen, the main target of the autoimmune response in patients with Sjogren's Syndrome (SS