Candidate T cell epitopes of the human La/SSB autoantigen
β Scribed by Marie L. Davies; Emma J. Taylor; Caroline Gordon; Stephen P. Young; Ken Welsh; Mike Bunce; B. Paul Wordsworth; Brian Davidson; Simon J. Bowman
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 72 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
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## Abstract La/SSB phosphoprotein is the target antigen of autoantibodies in sera of patients with SjΓΆgren's syndrome (SS) and systemic lupus erythematosus (SLE). Among other structural and function motifs, four phosphorylation sites are encompassed in the primary sequence of La/SSB. Two of them (T
## Abstract Tβcell epitopes are important components of the inappropriate response of the immune system to selfβproteins in autoimmune diseases. In this study, the candidate Tβcell epitopes of the La/SSB autoantigen, the main target of the autoimmune response in patients with Sjogren's Syndrome (SS
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