NMH studies of numerous somatostatin analogues have shown that all those showing biological activity adopt a o,, I turn-6 sheet conformation in dimethylsulfoxide (DMSO ) solution, but that this is not a sufficient condition for biological In this communication, we demonstrate that this backbone con
Conformational study of somatostatin analogues in methanol at low temperature
โ Scribed by Patricia M. F. Verheyden; David H. Coy; Georges Van Binst
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 390 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0749-1581
No coin nor oath required. For personal study only.
โฆ Synopsis
dominant conformation of the linear active analogue is shown to be the same as that of the active cyclic analogue; they both adopt a PI,' turn/bsbeet structure. The linear analogue with low activity has a similar conformation, which, however, is less stable.
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