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Conformational studies on peptides containing α,α-disubstituted α-amino acids: chiral cyclic α,α-disubstituted α-amino acid as an α-helical inducer

✍ Scribed by Demizu, Yosuke; Doi, Mitsunobu; Kurihara, Masaaki; Okuda, Haruhiro; Nagano, Masanobu; Suemune, Hiroshi; Tanaka, Masakazu

Book ID
118215011
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
948 KB
Volume
9
Category
Article
ISSN
1477-0520

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## Abstract A single chiral cyclic α,α‐disubstituted amino acid, (3__S__,4__S__)‐1‐amino‐(3,4‐dimethoxy)cyclopentanecarboxylic acid [(__S__,__S__)‐Ac~5~c^dOM^], was placed at the __N__‐terminal or __C__‐terminal positions of achiral α‐aminoisobutyric acid (Aib) peptide segments. The IR and ^1^H NMR