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Conformational Studies of Mono- and Bicyclic Parathyroid Hormone-Related Protein-Derived Agonists †

✍ Scribed by Mierke, Dale F.; Maretto, Stefano; Schievano, Elisabetta; DeLuca, Dominga; Bisello, Alessandro; Mammi, Stefano; Rosenblatt, Michael; Peggion, Evaristo; Chorev, Michael


Book ID
126081586
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
368 KB
Volume
36
Category
Article
ISSN
0006-2960

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Conformational studies of parathyroid ho
✍ Elisabetta Schievano; Stefano Mammi; Laura Silvestri; Vered Behar; Michael Rosen 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 483 KB

The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney. This binding occurs in spite of