Conformational studies of a bicyclic, lactam-constrained parathyroid hormone-related protein-derived agonist
โ Scribed by Elisabetta Schievano; Stefano Mammi; Alessandro Bisello; Michael Rosenblatt; Michael Chorev; Evaristo Peggion
- Book ID
- 111697529
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 162 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1075-2617
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The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney. This binding occurs in spite of
The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane receptor in spite of major differences between the two hormones in their amino acid sequence. Recently, it was shown that in (1-34)PTH/PTHrP segmental hy