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Conformational studies of a bicyclic, lactam-constrained parathyroid hormone-related protein-derived agonist

โœ Scribed by Elisabetta Schievano; Stefano Mammi; Alessandro Bisello; Michael Rosenblatt; Michael Chorev; Evaristo Peggion


Book ID
111697529
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
162 KB
Volume
5
Category
Article
ISSN
1075-2617

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๐Ÿ“œ SIMILAR VOLUMES


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The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney. This binding occurs in spite of

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The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane receptor in spite of major differences between the two hormones in their amino acid sequence. Recently, it was shown that in (1-34)PTH/PTHrP segmental hy