✦ LIBER ✦

Conformational investigations of cyclic dipeptides: Cyclo-glycyl-L-methionyl, cyclo-glycyl-D,L-norleucyl and cyclo-glycyl-D,L-norvalyl

✍ Scribed by I. Z. Siemion; B. Picur

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 440 KB
Volume: 22
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270220308

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✦ Synopsis

Abstract

The E~0~ rotamer of c‐Gly‐Met has been found to be almost as equally populated as the F rotamer at low temperatures, whereas in c‐Gly‐D,L‐Nle and c‐Gly‐D,L‐Nvl the F rotamer predominates. The increase of the E~0~ rotamer population parallels the increase of the boat diketopiperazine (DKP) ring conformation, in which Med side‐chain occupies a pseudoaxial position. Thermodynamic parameters for DKP ring inversion and for conformational transitions in the side‐chains were experimentally determined for each cyclic dipeptide investigated.

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