Conformational entropy in molecular recognition by proteins
β Scribed by Frederick, Kendra King; Marlow, Michael S.; Valentine, Kathleen G.; Wand, A. Joshua
- Book ID
- 109896782
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 285 KB
- Volume
- 448
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Recognition requires protein flexibility because it facilitates conformational rearrangements and inducedβfit mechanisms upon target binding. Intrinsic disorder is an extreme on the continuous spectrum of possible protein dynamics and its role in recognition may seem counterintuitive. H
## Abstract An important, but often neglected, contribution to the thermodynamics of protein folding is the loss of entropy that results from restricting the number of accessible sideβchain conformers in the native structure. Conformational entropy changes can be found by comparing the number of ac