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Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines

✍ Scribed by Balsamo, A.; Crotti, P.; Lapucci, A.; Macchia, B.; Macchia, F.; Del Tacca, M.; Mazzanti, L.; Ceserani, R.


Book ID
118158677
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
574 KB
Volume
22
Category
Article
ISSN
0022-2623

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## Abstract Conformational energy calculations using the MM2 (molecular mechanics II) program are reported for diastereoisomeric α‐ and β‐azabicyclanes (3‐methyl‐9‐methoxy‐9‐phenyl‐3‐azabicyclo [3.3.1] nonanes) which are prototypical phenyl‐axial and phenyl‐equatorial opiates. After energy minimiza