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Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes

✍ Scribed by Arif Esa; Allen E Coleman; Peter Edelmann; Santiago Silva; Christoph G Cremer; Siegfried Janz

Book ID
114135125
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
174 KB
Volume
127
Category
Article
ISSN
0165-4608

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## Abstract Abnormalities of immunoglobulin (Ig) heavy chain synthesis occurring in human B lymphoid cell lines of malignant origin suggest that the Ig heavy‐chain gene complex is involved in the 8:14 chromosome translocation which these cells carry.