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Conformational constraints for protein self-cleavage in the proteasome

โœ Scribed by Lars Ditzel; Robert Huber; Karlheinz Mann; Wolfgang Heinemeyer; Dieter H Wolf; Michael Groll

Book ID
115628580
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
794 KB
Volume
279
Category
Article
ISSN
0022-2836

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๐Ÿ“œ SIMILAR VOLUMES

Conformational constraint in protein lig
Conformational constraint in protein ligand design and the inconsistency of binding entropy
โœ D. Gomika Udugamasooriya; Mark R. Spaller ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 598 KB

## Abstract It is an accepted practice in ligand design to introduce conformational constraint with the expectation of improving affinity, justified by the theoretical possibility that an unfavorable change in binding entropy will be reduced. This rationale of minimizing the entropic penalty throug