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Conformational analysis of nucleic acids. Extended Huckel study of 5′ adenosine monophosphate (5′ AMP)

✍ Scribed by D. Vasilescu; J.N. Lespinasse; F. Camous; R. Cornillon


Book ID
115903119
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
229 KB
Volume
27
Category
Article
ISSN
0014-5793

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Conformational analysis of a cyclic nucl
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## Abstract The extended Hückel theory (EHT) was used as a quantum mechanical approach for the determination of the best conformation of cyclic AMP. Both geometrical and quantum mechanical studies were necessary to ascertain the configuration of the sugar ring and phosphate ring. This was due to th

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## Synopsis The molecular conformation of adenosine-5'-monophosphate (5'-AMP) in D20 (pH 8.1) has been investigated by the method of "DESERT" proposed earlier by Akasaka e t al. [J. Magn. Reson. 18,328 (1975)]. The reciprocal sixth-power-averaged distances F, ?3 between H(8) of the adenine ring an