Conformational analysis of elcatonin in solution
β Scribed by Kiyoshi OGAWA; Shigenori NISHIMURA; Masamitsu DOI; Yoshimasa KYOGOKU; Mitsuo HAYASHI; Yuji KOBAYASHI
- Book ID
- 115130851
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 778 KB
- Volume
- 222
- Category
- Article
- ISSN
- 1432-1327
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## Abstract The solution conformation of human calcitonin in a mixture of 60% water and 40% trifluoroethanol has been determined by the combined use of ^1^H NMR spectroscopy and distance geometry calculations with a distributed computing technique. ^1^H NMR spectroscopy provided 195 distance constr
## Synopsis The strategy and tactics of conformational analysis of cyclic peptides in solution is demonstrated by the example of cyclo(-D-Pro-Phe-TPhe-TYp-Phe-). Spin-locked experiments like rotating frame nuclear Overhauser enhancement spectroscopy (ROESY), ROTO, and TOCSY are successfully applie