Conformational analysis of a tyrosinase inhibitory cyclic pentapeptide, pseudostellarin A, from Pseudostellaria heterophylla

✍ Scribed by Hiroshi Morita; Takashi Kayashita; Koichi Takeya; Hideji Itokawa

• Book ID: 104204755
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 678 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)89393-5

✦ Synopsis

probational studies of ~ud~tell~n A were pcrformcd by a combination of bigb field NMR and computatiouai chemical evidences to elucidate a relatiouship between the structures and their tyrosiuase inhibitory activities in a series of cyclii puptides, pseudostellarins, and to establish a pharmacophore model. ~~~~~of~~A~~by~-and~ turn structures, fmed by trans-annular hydrogen bonds between Gly and Lcu.