Conformation of the carbonyl group in secondary amides
โ Scribed by C.R. Narayanan; B.M. Sawant
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 259 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
## Abstract Syntheses and analyses are described for incorporation of ^17^O from ^17^Oโenriched water into the carbonyl oxygen position of the ester and amide bonds in Oโ(transโpchlorocinnamoyl)โLโฮฒโphenyllactate and Nโ(benzoyl)โglycylโLโphenylalanine.
Evidence for the participation of neighboring -CONH 2 group in the ammonolysis of disubstituted amide was obtained. The surprising conversion of I into 3 in very. mild conditions is a process formed by two consecutive first order reactions. Kinetics were performed in ethanol at various temperatures
Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.