Conformation of some biologically active DI- and tri-substituted ureas
β Scribed by B. Hadjieva; V. Kalcheva; B. Galabov
- Book ID
- 103210887
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 212 KB
- Volume
- 238
- Category
- Article
- ISSN
- 0022-2860
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π SIMILAR VOLUMES
Selective hydrolysis of ~nimidodithioutes (3) leads to the thiocarbamutes (4), which can be easily transformed to the unsymmetrical ureas (5) by treatment with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene or carbon monoxide.
## Abstract Condensation of 4β(3__H__)βquinazolinone **(2)** with 4β(aminophenyl)βmercaptoacetic acid under the conditions of the Mannich reaction furnished compounds **3a** and **3b**. Reaction of **4** with 4β(aminoβphenyl)mercaptoacetic acid yielded **5** which when treated with aryl aldehydes g