𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Conformation of cyclic analogs of enkephalin. III. Effect of varying ring size

✍ Scribed by David Hall; Nicola Pavitt

Publisher
Wiley (John Wiley & Sons)
Year
1985
Tongue
English
Weight
513 KB
Volume
24
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Synopsis

A comparative study has been made using molecular mechanics of the ring entity of the active enkephalin analogs, Tyr-cyclo(-N'-D-XXX-Gly-Phe-Leu-), where XXX is variously A,pr, A,bu, and Orn. Several conformations are favored for all three, and the lower-energy models are compatible with a Gly3-Phe4 bend in the active form of enkephalin. Some difficulties in assuming standard geometries in conformational surveys are illustrated.

πŸ“œ SIMILAR VOLUMES

Conformation of cyclic analogs of enkeph
Conformation of cyclic analogs of enkephalin. II. Analogs containing a cystine bridge
✍ David Hall; Nicola Pavitt πŸ“‚ Article πŸ“… 1984 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 416 KB

A systematic survey has been made, using molecular mechanics, of the conformation of the ring entity of the enkephalin analogs, [~Cys~-~-Cys~]enkephalinamide and [D Cys2-~Cys5]enkephalinamide. These molecules are considerably more flexible than the analog Tyr-cyclo(Ny-DA,bu-Gly-Phe-Leu-), but the fa

Conformation of a cyclic tetrapeptide re
Conformation of a cyclic tetrapeptide related to an analog of enkephalin
✍ David Hall; Nicola Pavitt πŸ“‚ Article πŸ“… 1984 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 739 KB

A systematic survey has been made, using molecular mechanics, of the conformation of cycle(-NY-Mabu-Gly-Ala-Ala-), where Mabu is (R)-a-methyl-y-arninobutyric acid. This molecule corresponds to the 14-membered ring of the conformationally restricted, biologically active, Leu-enkephalin analog, Tyr-~~