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Conformation of cyclic analogs of enkephalin. II. Analogs containing a cystine bridge

✍ Scribed by David Hall; Nicola Pavitt

Publisher: Wiley (John Wiley & Sons)
Year: 1984
Tongue: English
Weight: 416 KB
Volume: 23
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360231114

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✦ Synopsis

A systematic survey has been made, using molecular mechanics, of the conformation of the ring entity of the enkephalin analogs, [~Cys~-~-Cys~]enkephalinamide and [D Cys2-~Cys5]enkephalinamide. These molecules are considerably more flexible than the analog Tyr-cyclo(Ny-DA,bu-Gly-Phe-Leu-), but the favored conformations of all three are very similar. The results of these studies are compatible with a Gly3-Phe' type II' bend in the active conformation of enkephalin.

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