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Configuration of phenoxymethyl- and 6-epi phenoxymethylpenicillin sulfoxides

โœ Scribed by Vlietinck, Arnold J.; Roets, Eugene; Vanderhaeghe, Hubert


Book ID
126324197
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
561 KB
Volume
39
Category
Article
ISSN
0022-3263

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Pseudopeptidic sulfoxides: relative stab
โœ Jean-Marc Poudrel; Peter Karuso ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 111 KB

The relative stability in solution of diastereomeric pseudopeptidic sulfoxides initially designed as FKBP inhibitors is used to assign the absolute conยฎguration at the sulfur atom. Decomposition is shown to occur via b-elimination of the corresponding sulfenic acid and alkene. Complementary studies