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Conditions affecting hydrodynamics-based gene delivery into mouse liver in vivo

✍ Scribed by Deng-Min Feng; Chen-Xia He; Chao-Yu Miao; Bin Lu; Wen-Jun Wu; You-Fa Ding; Jing-Lun Xue

Book ID: 108937585
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 206 KB
Volume: 31
Category: Article
ISSN: 0305-1870
DOI: 10.1111/j.1440-1681.2004.04125.x

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## Abstract ## Background Rapid intravenous injection of a large volume of plasmid DNA (pDNA), i.e. a transfection procedure based on hydrodynamics, is known to be an efficient and liver‐specific method of __in vivo__ gene delivery. However, the gene expression is transient. ## Methods We invest