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Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues

✍ Scribed by Viraj Kulkarni; Dhananjaya Saranath


Book ID
114394056
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
430 KB
Volume
40
Category
Article
ISSN
1368-8375

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## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in