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Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas

✍ Scribed by Éva Gömöri; József Pál; Bernadett Kovács; Tamás Dóczi


Book ID
115022991
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
522 KB
Volume
7
Category
Article
ISSN
1746-1596

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## Abstract Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O^6^‐methyl