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Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer

✍ Scribed by Yoshida, Rintaro; Miyashita, Kaname; Inoue, Mayuko; Shimamoto, Akiyoshi; Yan, Zhao; Egashira, Akinori; Oki, Eiji; Kakeji, Yoshishiro; Oda, Shinya; Maehara, Yoshihiko

Book ID: 109849325
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 612 KB
Volume: 19
Category: Article
ISSN: 1018-4813
DOI: 10.1038/ejhg.2010.216

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## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The