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Concurrent development of resistance to 6-azauridine and adenosine in a mouse cell line

✍ Scribed by S. Hashmi; S. R. May; R. S. Krooth; O. J. Miller

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
715 KB
Volume
86
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

A variant of the hypoxanthine‐guanine phosphoribosyltransferase deficient, and adenine phosphoribosyltransferase deficient mouse A9 cell line has been obtained by selecting cells which are resistant to 6‐azauridine. These cells are not only resistant to 6‐azauridine (5 × 10^−4^ M), but also to adenosine (10^−3^ M). Resistance persists indefinitely even in the absence of both compounds. The resistant cells are killed by 5‐fluorouridine (10^−6^ M), indicating that the part of the salvage pathway for pyrimidine ribonucleotide biosynthesis which is relevant to the action of 6‐azauridine is intact. The heritable change producing concurrent resistance to 6‐azauridine and adenosine probably involves the de novo pyrimidine biosynthetic pathway.

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