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Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study

✍ Scribed by Anatolio B. Cruz Jr.; Matilda Perkins; J. Bradley Aust; Charles A. Coltman Jr.; Ester B. Pollard; William S. Fletcher; Peter Kennedy; Daniel E. Lehane; Joaquin Mira; Joseph D. McCracken; Stephen D. Sorgen; Carey P. Page; Olga J. Pendleton; Eashwer Reddy; Joan Sapp; Frank Smith

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 446 KB
Volume: 20
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930200410

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✦ Synopsis

Abstract

Forty‐three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full‐dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long‐term survival duration was not greater than was that for historical controls.

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