Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
β Scribed by Richie Soong; Peter D Robbins; Brett R Dix; Fabienne Grieu; Berenice Lim; Simon Knowles; Kate E Williams; Gavin R Turbett; Anthony K House; Barry J Iacopetta
- Book ID
- 117253387
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 753 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1532-8392
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## RESULTS. DO7, an anti-p53 monoclonal antibody, showed p53 overexpression in 35 carcinomas (53%). Consensus primer PCR showed HPV infection in 12 carcinomas
The p53 tumor suppressor gene has proven to be one of the genes most often mutated in human cancers. It involves mainly point mutations leading to amino acid substitutions in the central region of the protein which impairs normal functions. Analysis of the mutational events that target the p53 gene